Interview questions for Pharma Quality Control

Are you interested in Pharma Quality Control jobs? Then searching for various interview Question and Answers to prepare well for the interview? Then your solution would be in Wisdomjobs, because here In we have provided you the complete detailed interview questions covering all nook and corner topics in Pharma Quality Control. To be precise on what exactly Pharma Quality Control is the important operation of the pharmaceutical industry

1. What Is Standard Deviation?

Standard deviation tells about the widely spread out of the measured analytical data points. Highly precised measurements are less standard deviation.

2. What Is Deference Between The Working Standard And Reference Standard?

Reference std is like USP,EP std , in this std we get COA including results of Potency by HPLC , NMR & XRPD data. whenever there is requirement of w.std preparation first we have get API rawmaterial from warehouse & we check assay , water content or LOD & Related substances aganist reference std . Some times we are doing analysis in duplicate & get mean value.then we decide final assay or potency value & it’s validity one year.

Suppose We Prepared Ph Buffer Solution In Lab.and Calibrate Against Nist Solution, And Same Shall Going To Used Up To 30 Days.

 3. Is It Possible To Stable Ph And Appearance? Suggest?

PH of the buffer solution will be change, as due to presence of nitrogen containing substances and also due to microbial growth. but if stored at 4 degree centi. it may used to some extent.

4. What Is Rs Test Why We Are Perfoming Rs Test?

RS stands for related substance, means by-products upon completion of reaction, or the unreacted portion present in the product. RS testing help us to identify the adequate quantitiy of these by-products or unreacted part. More over RS help us during the stability study to know any significant change in the nature of product during long storage in various climatic conditions

5. How To Calculate Signal To Noise Ratio By This Formula 2h/h Where H From Where And How To Measure?

The H is the height of the main peak and the h is the lowest height of a peak in the range of X5 the main peak (around the amin peak).

6. What Are The Main Differences Between High Performance Liquid Chromatography And Gas Chromatography?

o In HPLC the mobile phase is a liquid whereas in Gas Chromatography the mobile phase or carrier is a gas.
o HPLC is useful for analysis of samples which are liable to decompose at higher temperatures. GC involves high temperatures so compounds are stable at such temperatures.
o Gas Chromatography is applied for analysis of volatile compounds whereas non volatile compounds can be easily analyzed on HPLC
o Gas Chromatography cannot be used for analysis of high molecular weight molecules whereas HPLC has applications for separation and identification of very high molecular weight compounds
o HPLC requires higher operating pressures than GC because liquids require higher pressures than gases for transport through the system
o HPLC columns are short and wide in comparison to GC columns

7. Which Type Of Gc Detector Is Most Commonly Used? Explain Its Working Principle And What Are Its Limitations?

The most commonly used detector is the flame ionize detector. The sample is combusted with the help of fuel gas and oxidant in the detector body. Combustible sample components burn and produce ions and electrons which can conduct electricity through the flame. A large potential difference is applied at the burner tip and the collector electrode located above the flame and the current between the electrodes is measured. The detector is mass sensitive and response is not affected by carrier gas flow rate changes. However, the detector is not responsive to inorganic gases such as CO, O2, NH3, N2, CS2, CO2, etc.

8. What Are The Commonly Used Carrier Gases In Gc Analysis When Using Fid Detector?

Inert gases commonly used in analysis when using FID detector are Nitrogen and Helium. Nitrogen is more commonly used as it is less expensive than Helium. Purity of carrier gas should be more than 99.995% and on-line traps should be used to prevent residual moisture or other impurities from entering the system.